Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367962 | 0.78 | PIK3CA (0.48) | PIK3CAMTORAURKAAURKBPIK3CD | |
| SCHEMBL367961 | 0.78 | PIK3CA (0.48) | PIK3CAMTORAURKAAURKBPIK3CD | |
| SCHEMBL9905206 | 0.71 | PIK3CA (0.53) | PIK3CAMTOR | |
| SCHEMBL367915 | 0.66 | PIK3CA (0.47) | PIK3CAMTORMAP3K12AURKBLRRK2 | |
| SCHEMBL369429 | 0.66 | PIK3CA (0.47) | PIK3CAMTORMAP3K12AURKBLRRK2 | |
| SCHEMBL368584 | 0.65 | PIK3CA (0.45) | PIK3CAMTORAURKBLRRK2PIK3CD | |
| SCHEMBL359243 | 0.65 | PIK3CA (0.43) | PIK3CAMTORAURKBLRRK2PIK3CD | |
| SCHEMBL359242 | 0.65 | PIK3CA (0.43) | PIK3CAMTORAURKBLRRK2PIK3CD | |
| SCHEMBL368585 | 0.65 | PIK3CA (0.45) | PIK3CAMTORAURKBLRRK2PIK3CD | |
| SCHEMBL367393 | 0.65 | PIK3CA (0.48) | PIK3CAMTORMAP3K12AURKBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593450-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | Piramal Enterprises Limited (IN) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007926-A1 | SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-01-19 | — | — | WO | claimed |