Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD44 | P16070 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3383979 | 0.98 | CD44 (0.50) | CD44MAPTGAAKDM4ECHEK1 | |
| SCHEMBL9754424 | 0.85 | GAA (0.52) | CD44MAPTGAAKDM4ECHEK1 | |
| SCHEMBL658146 | 0.84 | CD44 (0.50) | CD44MAPTGAAKDM4ECHEK1 | |
| SCHEMBL11434378 | 0.78 | MAPT (0.42) | CD44MAPTGAAKDM4ECHEK1 | |
| SCHEMBL9614284 | 0.78 | CHEK1 (0.50) | CD44MAPTGAAKDM4ECHEK1 | |
| SCHEMBL106244 | 0.76 | — | — | |
| SCHEMBL16776729 | 0.76 | CD44 (0.72) | CD44GAAKDM4ETSHRACHE | |
| SCHEMBL20421691 | 0.76 | CD44 (0.46) | CD44MAPTGAAKDM4ECHEK1 | |
| SCHEMBL5708973 | 0.76 | CD44 (0.46) | CD44MAPTGAATSHRACHE | |
| SCHEMBL1911943 | 0.75 | MAPT (0.48) | MAPTGAAKDM4ECHEK1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
| CN-101137652-A | Pyrimidine compounds having tie2 (tek) inhibitory activity | ASTRAZENECA AB (SE) | 2008-03-05 | — | — | CN | disclosed |
| CN-1119148-C | Use of 'alpha' 1L agonists in treatment of incontinence | BOEHRINGER INGELHEIM KG (DE) | 2003-08-27 | — | — | CN | disclosed |
| US-4359398-A | Liquid crystal compositions with novel tris-azo dichroic dyes | GENERAL ELECTRIC COMPANY (US) | 1982-11-16 | — | — | US | disclosed |
| US-4350603-A | Novel tris-azo dyes and liquid crystal compositions made therewith | GENERAL ELECTRIC COMPANY (US) | 1982-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | TEK, TYMP, TIE1 | CD44 4486/4885MAPT 1426/4885GAA 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.