Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 16/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582920 | 1.00 | KDM4E (0.41) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL2247469 | 0.83 | OPRL1 (0.48) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL2240983 | 0.83 | OPRL1 (0.48) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL3582603 | 0.74 | CHRNA7 (0.52) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL3582606 | 0.74 | CHRNA7 (0.52) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL3595175 | 0.72 | OPRL1 (0.42) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL3595173 | 0.72 | OPRL1 (0.42) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL3587101 | 0.70 | KDM4E (0.47) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL3587098 | 0.70 | KDM4E (0.47) | KDM4EGAAMAPTOPRL1OPRM1 | |
| SCHEMBL3590742 | 0.68 | OPRL1 (0.45) | KDM4EGAAMAPTOPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086958-B1 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA LP (US) | 2015-01-14 | — | — | EP | claimed |
| US-8877779-B2 | Benzimidazole compound and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2014-11-04 | — | — | US | disclosed |
| CN-101622241-B | Benzimidazole compound and medical application thereof | MITSUBISHI TANABE PHARMA CORP | 2013-05-22 | — | — | CN | disclosed |
| US-20100120841-A1 | BENZIMIDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-05-13 | — | — | US | disclosed |
| CN-101622241-A | Benzimidazole compound and medical application thereof | MITSUBISHI TANABE PHARMA CORP | 2010-01-06 | — | — | CN | disclosed |
| EP-2128154-A1 | BENZIMIDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2009-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120841-A1 | BENZIMIDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF | ORMDL3, OXA1L, OGFRL1 | KDM4E 3547/4885GAA 1072/4885MAPT 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.