Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590059 | 0.88 | BRAF (0.76) | BRAFRAF1PKM | |
| SCHEMBL3599869 | 0.78 | BRAF (1.00) | BRAFRAF1PKM | |
| SCHEMBL3597847 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3599320 | 0.76 | BRAF (0.96) | BRAFRAF1 | |
| SCHEMBL3590672 | 0.75 | BRAF (0.93) | BRAFRAF1 | |
| SCHEMBL3601306 | 0.75 | BRAF (0.93) | BRAFRAF1PKM | |
| SCHEMBL3594240 | 0.75 | BRAF (0.84) | BRAFRAF1 | |
| SCHEMBL3587726 | 0.75 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3594954 | 0.75 | BRAF (0.77) | BRAFRAF1 | |
| SCHEMBL3593241 | 0.74 | BRAF (1.00) | BRAFRAF1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795249-B2 | Certain pyrazoline derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-09-14 | — | — | US | claimed |