Sugi Predict

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SCHEMBL3583947

SCHEMBL3583947

CN(C)C(=O)c1ccn(-c2cccc(Nc3ccc(Cl)cc3)n2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 1/20 0.45
▸ CNR2 P34972 1/20 0.45
▸ MALT1 Q9UDY8 1/20 0.37
▸ SCN9A Q15858 2/20 0.37
▸ EGFR P00533 1/20 0.37
▸ ERBB3 P21860 1/20 0.37
▸ GBA1 P04062 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ GRM5 P41594 1/20 0.36
▸ MAPT P10636 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ CDK4 P11802 1/20 0.35
▸ CCND1 P24385 1/20 0.35
▸ P2RX3 P56373 2/20 0.35
▸ KDM1A O60341 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ CYP1A2 P05177 2/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ USP2 O75604 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3578621 0.86 CNR1 (0.48) CNR1CNR2SCN9AEGFRERBB3
SCHEMBL3575055 0.82 HTT (0.44) CNR1CNR2EGFRRAB9AMAPT
SCHEMBL3577056 0.76 CNR1 (0.45) CNR1CNR2SCN9AEGFRERBB3
SCHEMBL3577903 0.71 NOTUM (0.49) CNR1CNR2SCN9AEGFRERBB3
SCHEMBL3571139 0.66 MAPT (0.54) CNR1CNR2EGFRERBB3RAB9A
SCHEMBL19690904 0.66 KDM1A (0.43) RAB9AMAPTKDM1ANPC1CYP1A2
SCHEMBL19690886 0.66 HTT (0.43) EGFRGBA1MAPTP2RX3NPC1
SCHEMBL3579788 0.65 SCN9A (0.42) CNR1CNR2SCN9AEGFRERBB3
SCHEMBL19690887 0.65 NPC1 (0.48) RAB9AMAPTTSHRKDM1ANPC1
SCHEMBL13483402 0.64 NTRK1 (0.37) MALT1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100035934-A1 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S 2010-02-11 — — US claimed
EP-2114916-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NeuroSearch A/S (DK) 2009-11-11 — — EP claimed
WO-2008092942-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2008-08-07 — — WO claimed
US-20100035934-A1 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S 2010-02-11 — — US disclosed
EP-2114916-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NeuroSearch A/S (DK) 2009-11-11 — — EP disclosed
WO-2008092942-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2008-08-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100035934-A1 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS KCNJ2, KCNA3, KCNQ1 CNR1 608/4885CNR2 470/4885MALT1 4227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.