⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1058224 | 0.81 | — | — | |
| SCHEMBL13282088 | 0.73 | — | — | |
| SCHEMBL10022894 | 0.73 | — | — | |
| SCHEMBL10022895 | 0.72 | — | — | |
| SCHEMBL32682429 | 0.71 | — | — | |
| SCHEMBL10022893 | 0.71 | — | — | |
| SCHEMBL823853 | 0.69 | — | — | |
| Urea SCHEMBL5848172 | 0.69 | TDP1 (0.36) | — | |
| SCHEMBL12193540 | 0.69 | — | — | |
| SCHEMBL16104364 | 0.67 | PAOX (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842822-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090298925-A1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | DURST GREGORY LEE | 2009-12-03 | — | — | US | disclosed |
| US-7585985-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080312312-A1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | DURST GREGORY LEE | 2008-12-18 | — | — | US | disclosed |
| US-7442812-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1626974-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | disclosed |
| CN-100374444-C | Substituted benzopyran compounds as selective beta-estrogen receptor agonists | YILE LILY CO LTD (US) | 2008-03-12 | — | — | CN | disclosed |
| US-20070106082-A1 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20060194871-A1 | Heterocyclic mchr1 antagoists | SMITHKLINE BEECHAM CORPORATION | 2006-08-31 | — | — | US | disclosed |
| CN-1777614-A | Substituted benzopyran compounds as selective beta-estrogen receptor agonists | LILLY CO ELI (US) | 2006-05-24 | — | — | CN | disclosed |
| EP-1626974-A2 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2006-02-22 | — | — | EP | disclosed |
| EP-1618112-A1 | HETEROCYCLIC MCHR1 ANTAGONISTS | SmithKline Beecham Corporation (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094400-A2 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
| WO-2004092181-A1 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-10-28 | — | — | WO | disclosed |