Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.67 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.67 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.67 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.67 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.67 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.67 |
| ▸ | GSK3A | P49840 | 2/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.67 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.67 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.67 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.67 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577449 | 0.90 | PIM1 (0.82) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3580315 | 0.90 | MAP4K4 (0.82) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3589367 | 0.87 | MAP4K4 (0.65) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL6580865 | 0.86 | MAP4K4 (0.57) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3578575 | 0.86 | PIM1 (0.77) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3585981 | 0.85 | ADORA2A (0.55) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL6581364 | 0.83 | MAP4K4 (0.62) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3577816 | 0.81 | MAP4K4 (1.00) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3575237 | 0.81 | MAP4K4 (1.00) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL6581316 | 0.80 | MAP4K4 (0.55) | PIM1PIM3AURKBCLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |