Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712838 | 1.00 | TACR1 (0.44) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2712836 | 1.00 | TACR1 (0.44) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4549803 | 0.85 | TACR1 (0.41) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2862029 | 0.80 | HTR2C (0.46) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2862032 | 0.80 | HTR2C (0.46) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4507024 | 0.74 | HTR2C (0.41) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8196031 | 0.74 | PSEN1 (0.50) | HTR2CKDM1A | |
| SCHEMBL2886373 | 0.74 | PSEN1 (0.50) | HTR2CKDM1A | |
| SCHEMBL4507030 | 0.74 | HTR2C (0.41) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28199047 | 0.73 | HTR2C (0.49) | TACR1MAPTHTR2CLMNAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013171-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER S DISEASE | MERCK SHARP & DOHME (GB) | 2013-05-15 | — | — | EP | disclosed |
| US-8389547-B2 | Piperidines and related compounds for the treatment of Alzheimer's disease | MERCK SHARP & DOHME LLC | 2013-03-05 | — | — | US | disclosed |
| US-20100048623-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LLC | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048623-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE1, PSEN1, BACE2 | TACR1 316/4885TP53 4078/4885CYP1A2 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.