⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41166 | 1.00 | — | — | |
| SCHEMBL11287329 | 1.00 | — | — | |
| SCHEMBL17449732 | 0.79 | CYP3A4 (0.32) | — | |
| SCHEMBL12851469 | 0.79 | CYP3A4 (0.32) | — | |
| SCHEMBL5137869 | 0.79 | CYP3A4 (0.32) | — | |
| SCHEMBL8021752 | 0.76 | — | — | |
| SCHEMBL8007391 | 0.76 | — | — | |
| SCHEMBL308246 | 0.76 | — | — | |
| SCHEMBL8991581 | 0.76 | — | — | |
| SCHEMBL11277667 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101595103-A | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | CN | claimed |
| US-20090270390-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA (SE) | 2009-10-29 | — | — | US | claimed |
| CN-101563340-A | 2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | CN | claimed |
| US-20090233926-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA (SE) | 2009-09-17 | — | — | US | claimed |
| EP-2064203-A1 | 2-BENZIMIDAZ0LYL-6-M0RPH0LIN0-4-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-06-03 | — | — | EP | claimed |
| EP-2057147-A1 | PYRIMIDINE DERIVATIVES | Astra Zeneca AB (SE) | 2009-05-13 | — | — | EP | claimed |
| WO-2008032064-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |
| WO-2008032091-A1 | 4-BENZIMIDAZ0LYL-6-M0RPH0LIN0-2-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |
| WO-2008032060-A1 | 4-BENZIMIDAZ0LYL-6-M0RPH0LIN0-2-PIPERAZINYLPYRIMIDINE DERIVATIVES AS P13K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |
| WO-2008032072-A1 | 2-BENZIMIDAZ0LYL-6-M0RPH0LIN0-4-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |
| WO-2008032089-A1 | 4-BENZIMIDAZ0LYL-2-M0RPH0LIN0-6-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |
| WO-2007066099-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | claimed |
| WO-2007066103-A1 | PYRIMIDINE DERIVATIVES AS CLASS I PI3K INHIBITOR | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | claimed |
| US-9840537-B2 | Selective delivery molecules and methods of use | AVELAS BIOSCIENCES, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-20170044214-A1 | SELECTIVE DELIVERY MOLECULES AND METHODS OF USE | AVELAS ACQUISITION CORPORATION | 2017-02-16 | — | — | US | disclosed |
| US-20160220707-A1 | SELECTIVE DELIVERY MOLECULES AND METHODS OF USE | AVELAS ACQUISITION CORPORATION | 2016-08-04 | — | — | US | disclosed |
| WO-2007066099-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |
| US-5030732-A | Antiacterial agents | MERCK & CO., INC. (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0282219-B1 | AMINOETHYLPHOSPHINIC ACID DERIVATIVES | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1991-07-03 | — | — | EP | disclosed |
| EP-0282219-A1 | Aminoethylphosphinic acid derivatives | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1988-09-14 | — | — | EP | disclosed |