Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | TYK2 | P29597 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358235 | 0.82 | IRAK4 (0.69) | IRAK4LMNAIRAK1 | |
| SCHEMBL359927 | 0.82 | IRAK4 (1.00) | IRAK4LMNAIRAK1 | |
| SCHEMBL359354 | 0.81 | IRAK4 (1.00) | IRAK4IRAK1JAK2JAK1TYK2 | |
| SCHEMBL28264009 | 0.78 | IRAK4 (0.67) | IRAK4LMNA | |
| SCHEMBL359977 | 0.77 | IRAK4 (1.00) | IRAK4IRAK1 | |
| SCHEMBL360671 | 0.77 | IRAK4 (0.84) | IRAK4IRAK1 | |
| SCHEMBL359711 | 0.77 | IRAK4 (1.00) | IRAK4LMNAIRAK1 | |
| SCHEMBL358955 | 0.77 | IRAK4 (1.00) | IRAK4IRAK1 | |
| SCHEMBL357383 | 0.77 | IRAK4 (1.00) | IRAK4LMNAIRAK1 | |
| SCHEMBL358924 | 0.76 | IRAK4 (1.00) | IRAK4LMNAIRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | IRAK4 1/4885LMNA 2020/4885IRAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.