Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 4/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 5/20 | 0.32 |
| ▸ | KDR | P35968 | 5/20 | 0.32 |
| ▸ | TEK | Q02763 | 5/20 | 0.32 |
| ▸ | MET | P08581 | 4/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3553002 | 0.82 | PPARG (0.38) | SREBF2TRPA1NR1H2NR1H3PPARG | |
| SCHEMBL13283071 | 0.70 | NR1H2 (0.33) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3554098 | 0.69 | PTGER3 (0.39) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL3545568 | 0.68 | TLR8 (0.40) | NR1H2NR1H3PPARGKDM4EALDH1A1 | |
| SCHEMBL14625118 | 0.68 | PPARG (0.43) | SREBF2PPARGKDM4EALDH1A1GAA | |
| SCHEMBL3547487 | 0.67 | PPARG (0.48) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL13114569 | 0.66 | PPARG (0.41) | NR1H2NR1H3PPARGKDM4EHPGD | |
| SCHEMBL3550118 | 0.64 | HPGD (0.41) | PPARGKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3551052 | 0.63 | FGFR2 (0.36) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL13114528 | 0.62 | PPARG (0.42) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168164-A1 | Antidiabetic Oxazolidinediones and Thiazolidinediones | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168164-A1 | Antidiabetic Oxazolidinediones and Thiazolidinediones | PPARD, PPARA, PPARG | SREBF2 49/4885TRPA1 3320/4885NR1H2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.