Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.55 |
| ▸ | MTOR | P42345 | 7/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3606324 | 0.86 | PIK3CA (0.56) | PIK3CAPIK3CDMTORCHEK1ATR | |
| SCHEMBL3592485 | 0.84 | PIK3CA (0.79) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3603311 | 0.84 | PIK3CA (0.66) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3602667 | 0.83 | PIK3CA (0.70) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3601699 | 0.83 | PIK3CA (0.79) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3603843 | 0.82 | PIK3CA (0.66) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3597409 | 0.82 | PIK3CA (0.64) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3604012 | 0.82 | PIK3CA (0.64) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3605953 | 0.81 | PIK3CA (0.72) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3584434 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750003-B2 | Compounds-943 | ASTRAZENECA AB (SE) | 2010-07-06 | — | — | US | disclosed |