Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.73 |
| ▸ | CA2 | P00918 | 8/20 | 0.73 |
| ▸ | CA12 | O43570 | 7/20 | 0.73 |
| ▸ | CA7 | P43166 | 7/20 | 0.73 |
| ▸ | CA9 | Q16790 | 7/20 | 0.73 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | XDH | P47989 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231885 | 0.87 | CA1 (0.58) | CA1CA2CA12CA7CA9 | |
| SCHEMBL475680 | 0.87 | CA1 (0.58) | CA1CA2CA12CA7CA9 | |
| SCHEMBL46504 | 0.85 | CA12 (0.91) | CA1CA2CA12CA7CA9 | |
| Methyl 3,5-Dihydroxybenzoate SCHEMBL38869 | 0.85 | CA1 (1.00) | CA1CA2CA12CA7CA9 | |
| SCHEMBL15580328 | 0.80 | CA12 (0.45) | CA1CA2CA12CA7CA9 | |
| SCHEMBL30530249 | 0.80 | KDM4E (0.50) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3354749 | 0.80 | KDM4E (0.50) | CA1CA2CA12CA7CA9 | |
| SCHEMBL16925556 | 0.80 | ATM (0.52) | CA1CA2CA12CA7CA9 | |
| SCHEMBL16960586 | 0.80 | CA1 (0.50) | CA1CA2CA12CA7CA9 | |
| SCHEMBL31401260 | 0.80 | ATM (0.52) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1600442-B1 | HETEROARYLCARBAMOYLBENZENE DERIVATIVE | MSD KK (JP) | 2018-01-17 | — | — | EP | disclosed |
| EP-2185570-B1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS INC (US) | 2014-03-19 | — | — | EP | disclosed |
| US-7754743-B2 | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |
| CN-101712657-A | heteroarylcarbamoylbenzene derivative | BANYU PHARMA CO LTD | 2010-05-26 | — | — | CN | disclosed |
| CN-100591671-C | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMA CO LTD | 2010-02-24 | — | — | CN | disclosed |
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | MSD K.K. (JP) | 2009-01-15 | — | — | US | disclosed |
| US-7432287-B2 | Heteroarylcarbamoylbenzene derivative | BANYU PHARMECEUTICAL CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | MSD K.K. (JP) | 2006-07-27 | — | — | US | disclosed |
| CN-1777589-A | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMA CO LTD (JP) | 2006-05-24 | — | — | CN | disclosed |
| EP-1600442-A1 | HETEROARYLCARBAMOYLBENZENE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | GCK, GCKR, KHK | CA1 2194/4885CA2 593/4885CA12 2609/4885 |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | GCK, GCKR, GALK1 | CA1 3859/4885CA2 1370/4885CA12 3515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.