Sugi Predict

Sugi Predict / Compounds / SCHEMBL3603559

SCHEMBL3603559

SCHEMBL3603559

Nc1ccc(-c2nc(CS(=O)(=O)c3ccccc3)cc(N3CCOCC3)n2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 10/20 0.70
▸ PIK3CA P42336 8/20 0.68
▸ LMNA P02545 2/20 0.68
▸ HTT P42858 2/20 0.68
▸ ALDH1A1 P00352 2/20 0.68
▸ KDM4E B2RXH2 1/20 0.68
▸ POLB P06746 2/20 0.55
▸ KMT2A Q03164 2/20 0.54
▸ ATR Q13535 2/20 0.54
▸ CYP2C9 P11712 2/20 0.53
▸ PIK3CD O00329 1/20 0.52
▸ NPSR1 Q6W5P4 2/20 0.51
▸ MAPT P10636 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ MAPK1 P28482 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ PIK3CB P42338 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1271730 0.92 MTOR (0.77) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL739736 0.88 MTOR (0.73) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL1271886 0.88 MTOR (0.66) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL1272274 0.86 MTOR (0.64) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL1271439 0.86 MTOR (0.81) MTORPIK3CALMNAPOLBKMT2A
SCHEMBL3598789 0.86 MTOR (0.61) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL3603685 0.85 PIK3CA (0.63) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL1272376 0.84 MTOR (0.67) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL3594878 0.84 PIK3CA (0.61) MTORPIK3CALMNAHTTALDH1A1
SCHEMBL1271555 0.84 MTOR (0.64) MTORPIK3CALMNAHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2057140-B1 MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS ASTRAZENECA AB (SE) 2012-08-08 — — EP disclosed
EP-2057140-B1 MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS ASTRAZENECA AB (SE) 2012-08-08 — — EP disclosed
US-7750003-B2 Compounds-943 ASTRAZENECA AB (SE) 2010-07-06 — — US disclosed
US-7750003-B2 Compounds-943 ASTRAZENECA AB (SE) 2010-07-06 — — US disclosed
US-7750003-B2 Compounds-943 ASTRAZENECA AB (SE) 2010-07-06 — — US disclosed
US-20080171743-A1 Transcutaneous immunostimulation ASTRAZENECA AB (SE) 2008-07-17 — — US disclosed
US-20080171743-A1 Transcutaneous immunostimulation ASTRAZENECA AB (SE) 2008-07-17 — — US disclosed
US-20080171743-A1 Transcutaneous immunostimulation ASTRAZENECA AB (SE) 2008-07-17 — — US disclosed
WO-2008023159-A1 MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS ASTRAZENECA AB (SE) 2008-02-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080171743-A1 Transcutaneous immunostimulation NFATC1, TLR9, MTOR MTOR 3/4885PIK3CA 20/4885LMNA 4614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.