Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.61 |
| ▸ | MTOR | P42345 | 9/20 | 0.54 |
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262466 | 0.92 | PIK3CA (0.53) | PIK3CAPIK3CDMTORATRPIK3CG | |
| SCHEMBL13257087 | 0.92 | PIK3CA (0.63) | PIK3CAPIK3CDMTORATRPIK3CG | |
| SCHEMBL3602214 | 0.90 | PIK3CA (0.63) | PIK3CAPIK3CDMTORATRPIK3CG | |
| SCHEMBL8213908 | 0.89 | PIK3CA (0.57) | PIK3CAPIK3CDMTORATRPIK3CG | |
| SCHEMBL3602666 | 0.88 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3596872 | 0.87 | PIK3CA (0.62) | PIK3CAPIK3CDMTORATRPIK3CG | |
| SCHEMBL3604038 | 0.86 | PIK3CA (0.81) | PIK3CAPIK3CDMTORATRPIK3CG | |
| SCHEMBL3609044 | 0.84 | PIK3CA (0.63) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3592954 | 0.84 | PIK3CA (0.63) | PIK3CAPIK3CDMTORPIK3CGCYP2C9 | |
| SCHEMBL3600812 | 0.84 | PIK3CA (0.58) | PIK3CAPIK3CDMTORATRPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| US-7750003-B2 | Compounds-943 | ASTRAZENECA AB (SE) | 2010-07-06 | — | — | US | disclosed |
| EP-2057140-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-13 | — | — | EP | disclosed |
| US-20080171743-A1 | Transcutaneous immunostimulation | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171743-A1 | Transcutaneous immunostimulation | NFATC1, TLR9, MTOR | PIK3CA 20/4885PIK3CD 19/4885MTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.