Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 6/20 | 0.74 |
| ▸ | CDK1 | P06493 | 9/20 | 0.59 |
| ▸ | IGF1R | P08069 | 9/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.59 |
| ▸ | BRAF | P15056 | 9/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.59 |
| ▸ | JAK1 | P23458 | 9/20 | 0.59 |
| ▸ | CDK2 | P24941 | 9/20 | 0.59 |
| ▸ | AXL | P30530 | 9/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602538 | 0.93 | SMO (0.65) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL20420616 | 0.91 | SMO (0.71) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3601037 | 0.89 | SMO (0.65) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3609609 | 0.87 | SMO (0.61) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3606560 | 0.87 | SMO (0.61) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3611716 | 0.85 | SMO (0.67) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3607196 | 0.85 | SMO (1.00) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3599636 | 0.85 | SMO (0.63) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL3601569 | 0.83 | SMO (0.76) | SMOCDK1IGF1RFGFR1BRAF | |
| SCHEMBL13444952 | 0.82 | SMO (1.00) | SMOCDK1IGF1RFGFR1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137162-B1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2018-08-01 | — | — | EP | claimed |
| US-8536168-B2 | Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway | NOVARTIS AG (CH) | 2013-09-17 | — | — | US | claimed |
| CN-101657430-B | Organic compounds and uses thereof | NOVARTIS AG CH | 2013-05-01 | — | — | CN | claimed |
| US-20100069368-A1 | Organic Compounds and Their Uses | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | claimed |
| CN-101657430-A | Organic compounds and uses thereof | NOVARTIS AG CH | 2010-02-24 | — | — | CN | claimed |
| EP-2137162-A1 | ORGANIC COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-12-30 | — | — | EP | claimed |
| WO-2008110611-A1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2008-09-18 | — | — | WO | claimed |
| EP-2137162-B1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2018-08-01 | — | — | EP | disclosed |
| US-8536168-B2 | Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway | NOVARTIS AG (CH) | 2013-09-17 | — | — | US | disclosed |
| US-8536168-B2 | Benzyl and pyridinyl derivatives as modulators of the hedgehog signaling pathway | NOVARTIS AG (CH) | 2013-09-17 | — | — | US | disclosed |
| US-20100069368-A1 | Organic Compounds and Their Uses | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | disclosed |
| US-20100069368-A1 | Organic Compounds and Their Uses | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | disclosed |
| WO-2008110611-A1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069368-A1 | Organic Compounds and Their Uses | SHH, GLI1, VHL | SMO 5/4885CDK1 479/4885IGF1R 1791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.