Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871324 | 0.90 | NPC1 (0.49) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL9176879 | 0.83 | NPC1 (0.46) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL5534699 | 0.83 | NPC1 (0.42) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL4943705 | 0.83 | DYRK1A (0.44) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL506620 | 0.82 | NPC1 (0.51) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL5542288 | 0.82 | NPC1 (0.41) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL27610369 | 0.82 | CLK1 (0.49) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL29221351 | 0.81 | CLK1 (0.51) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL5543747 | 0.81 | NPC1 (0.41) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL20511818 | 0.80 | NPC1 (0.40) | NPC1RAB9AKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007510-A1 | COMPOUNDS FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-19 | — | — | WO | disclosed |