Sugi Predict

Sugi Predict / Compounds / SCHEMBL3606264

SCHEMBL3606264

SCHEMBL3606264

CCc1cc(-c2ccc(OC)c(OC3CCCO3)c2)n(-c2cccc(C)c2C)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 2/20 0.45
▸ MAPT P10636 1/20 0.39
▸ SLC16A3 O15427 6/20 0.38
▸ SLC16A1 P53985 6/20 0.38
▸ PI4KB Q9UBF8 1/20 0.36
▸ CACNA1B Q00975 2/20 0.35
▸ CACNB4 O00305 1/20 0.35
▸ CACNA1A O00555 1/20 0.35
▸ CACNA1G O43497 1/20 0.35
▸ CACNG3 O60359 1/20 0.35
▸ CACNA1F O60840 1/20 0.35
▸ CACNA1H O95180 1/20 0.35
▸ CACNB3 P54284 1/20 0.35
▸ CACNA2D1 P54289 1/20 0.35
▸ CACNG7 P62955 1/20 0.35
▸ CACNA1D Q01668 1/20 0.35
▸ CACNB1 Q02641 1/20 0.35
▸ CACNG1 Q06432 1/20 0.35
▸ CACNB2 Q08289 1/20 0.35
▸ CACNA1S Q13698 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3606095 0.93 PDE4B (0.44) PDE4BSLC16A3SLC16A1PI4KBCACNA1B
SCHEMBL3604368 0.89 PDE4B (0.45) PDE4BMAPTPI4KBCACNA1BCACNB4
SCHEMBL4194985 0.85 PDE4B (0.42) PDE4BMAPTPI4KBTSHRKDM4E
SCHEMBL3614484 0.82 PDE4B (0.44) PDE4BSLC16A3SLC16A1PI4KBCACNA1B
SCHEMBL3608923 0.79 PDE4B (0.46) PDE4BSLC16A3SLC16A1ALDH1A1PDE4D
SCHEMBL3607474 0.78 PDE4B (0.42) PDE4BPI4KBTSHRPDE4D
SCHEMBL3615330 0.78 PDE4B (0.49) PDE4BMAPTKDM4EALDH1A1PDE4D
SCHEMBL3604998 0.78 SLC16A3 (0.46) PDE4BSLC16A3SLC16A1PDE4D
SCHEMBL3615239 0.77 PDE4B (0.43) PDE4BSLC16A3SLC16A1CACNA1BCACNB4
SCHEMBL3615795 0.74 NPC1 (0.46) PDE4BMAPTKDM4EALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7495017-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION (US) 2009-02-24 — — US claimed
US-20070203197-A1 Phosphodiesterase 4 inhibitors HOPPER ALLEN 2007-08-30 — — US claimed
EP-1631568-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceuticals Corporation (US) 2006-03-08 — — EP claimed
US-20040229918-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2004-11-18 — — US claimed
WO-2004094411-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2004-11-04 — — WO claimed
US-7723348-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION (US) 2010-05-25 — — US disclosed
US-20090221661-A1 PHOSPHODIESTERASE 4 INHIBITORS HOPPER ALLEN 2009-09-03 — — US disclosed
US-7495017-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION (US) 2009-02-24 — — US disclosed
US-7432266-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION (US) 2008-10-07 — — US disclosed
US-20080207660-A1 PHOSPHODIESTERASE 4 INHIBITORS HOPPER ALLEN 2008-08-28 — — US disclosed
US-20070254913-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2007-11-01 — — US disclosed
US-20070203197-A1 Phosphodiesterase 4 inhibitors HOPPER ALLEN 2007-08-30 — — US disclosed
EP-1799673-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceuticals Corporation (US) 2007-06-27 — — EP disclosed
US-7226930-B2 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICAL CORPORATION (US) 2007-06-05 — — US disclosed
US-20060154960-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2006-07-13 — — US disclosed
WO-2006044528-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2006-04-27 — — WO disclosed
EP-1631568-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceuticals Corporation (US) 2006-03-08 — — EP disclosed
US-20040229918-A1 Phosphodiesterase 4 inhibitors MEMORY PHARMACEUTICALS CORPORATION 2004-11-18 — — US disclosed
WO-2004094411-A1 PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2004-11-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254913-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 PDE4B 2/4885MAPT 3815/4885SLC16A3 1854/4885
US-20070203197-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 PDE4B 2/4885MAPT 3815/4885SLC16A3 1854/4885
US-20080207660-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE4B, PDE12 PDE4B 2/4885MAPT 3815/4885SLC16A3 1854/4885
US-20060154960-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 PDE4B 2/4885MAPT 3815/4885SLC16A3 1854/4885
US-20090221661-A1 PHOSPHODIESTERASE 4 INHIBITORS PDE4A, PDE4B, PDE12 PDE4B 2/4885MAPT 3815/4885SLC16A3 1854/4885
US-20040229918-A1 Phosphodiesterase 4 inhibitors PDE4A, PDE4B, PDE12 PDE4B 2/4885MAPT 3815/4885SLC16A3 1854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.