Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GLP1R | P43220 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3615137 | 0.87 | NPC1 (0.40) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3610957 | 0.84 | NPC1 (0.38) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3609801 | 0.82 | SMN1; SMN2 (0.55) | KDM4ESMN1; SMN2LMNACYP1A2CYP2C19 | |
| SCHEMBL3602437 | 0.80 | MAOB (0.40) | RAB9AKDM4ESMN1; SMN2LMNACYP1A2 | |
| SCHEMBL3616668 | 0.77 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL3605605 | 0.76 | CYP1A2 (0.38) | CYP3A4SMN1; SMN2LMNACYP1A2CYP2C19 | |
| SCHEMBL3599883 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4130076 | 0.75 | SMN1; SMN2 (0.50) | USP2CYP3A4NPC1RAB9AKDM4E | |
| SCHEMBL3609157 | 0.75 | SMN1; SMN2 (0.37) | SMN1; SMN2CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL3607161 | 0.75 | SMN1; SMN2 (0.40) | KDM4ESMN1; SMN2CYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016396-A1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-21 | — | — | US | disclosed |
| EP-2128138-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016396-A1 | PYRAZOLE COMPOUND | SLC5A1, SLC5A2, GLP1R | USP2 4721/4885CYP3A4 71/4885NPC1 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.