Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.87 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.87 |
| ▸ | FLT3 | P36888 | 9/20 | 0.69 |
| ▸ | FLT4 | P35916 | 8/20 | 0.69 |
| ▸ | KIT | P10721 | 7/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.62 |
| ▸ | CSF1R | P07333 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.62 |
| ▸ | FGR | P09769 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608079 | 1.00 | NTRK1 (0.87) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3599980 | 0.93 | NTRK1 (1.00) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3600617 | 0.93 | NTRK1 (0.84) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3599984 | 0.93 | NTRK1 (1.00) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3600615 | 0.93 | NTRK1 (0.84) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3595579 | 0.92 | NTRK1 (0.90) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3595580 | 0.92 | NTRK1 (0.90) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL13256110 | 0.90 | NTRK1 (0.92) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3599568 | 0.90 | NTRK1 (0.92) | NTRK1NTRK3FLT3FLT4KIT | |
| SCHEMBL3593070 | 0.90 | NTRK1 (0.90) | NTRK1NTRK3FLT3FLT4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168182-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-07-01 | — | — | US | claimed |
| CN-101541788-A | Compounds and compositions as kinase inhibitors | IRM LLC (VG) | 2009-09-23 | — | — | CN | claimed |
| US-20100168182-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-07-01 | — | — | US | disclosed |
| EP-2102190-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008073480-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168182-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NTRK2, PDGFRB, PDGFRA | NTRK1 4/4885NTRK3 5/4885FLT3 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.