Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 5/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 7/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596448 | 0.86 | KHK (0.39) | SSTR5KHKNR3C2PIK3CD | |
| SCHEMBL3607823 | 0.86 | KHK (0.41) | SSTR5KHKPIK3CD | |
| SCHEMBL3607684 | 0.86 | KHK (0.44) | SSTR5KHKNR3C2PIK3CDMAPT | |
| SCHEMBL3607574 | 0.86 | KHK (0.42) | KHKPIK3CD | |
| SCHEMBL3591073 | 0.86 | KHK (0.38) | KHKNR3C2PIK3CDALDH1A1 | |
| SCHEMBL3606628 | 0.85 | PIK3CD (0.38) | MERTKAXLSSTR5KHKNR3C2 | |
| SCHEMBL3603030 | 0.84 | KHK (0.43) | MERTKAXLTYRO3KHKPIK3CD | |
| SCHEMBL3600483 | 0.84 | MAPK9 (0.44) | KHKPIK3CD | |
| SCHEMBL3600193 | 0.83 | PIK3CD (0.38) | SSTR5KHKPIK3CDOPRM1 | |
| SCHEMBL3603806 | 0.83 | KHK (0.41) | MERTKAXLTYRO3KHKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723348-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |
| US-7432266-B2 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-20080207660-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2008-08-28 | — | — | US | disclosed |
| US-20070254913-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2007-11-01 | — | — | US | disclosed |
| US-20060154960-A1 | Phosphodiesterase 4 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254913-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE4B, PDE12 | MERTK 3644/4885AXL 3795/4885TYRO3 4015/4885 |
| US-20080207660-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE12 | MERTK 3644/4885AXL 3795/4885TYRO3 4015/4885 |
| US-20060154960-A1 | Phosphodiesterase 4 inhibitors | PDE4A, PDE4B, PDE12 | MERTK 3644/4885AXL 3795/4885TYRO3 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.