Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.47 |
| ▸ | AKT2 | P31751 | 15/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362017 | 0.93 | AKT1 (0.46) | AKT1AKT2BRD4 | |
| SCHEMBL362285 | 0.86 | AKT1 (0.48) | AKT1AKT2 | |
| SCHEMBL10279771 | 0.85 | AKT1 (0.46) | AKT1AKT2 | |
| SCHEMBL10279772 | 0.78 | AKT1 (0.44) | AKT1AKT2 | |
| SCHEMBL362088 | 0.76 | AKT1 (0.57) | AKT1AKT2 | |
| SCHEMBL362037 | 0.74 | AKT1 (0.46) | AKT1AKT2BRD4TOP2A | |
| SCHEMBL10279755 | 0.73 | AKT1 (0.51) | AKT1AKT2TACR3 | |
| SCHEMBL362189 | 0.73 | AKT1 (0.52) | AKT1AKT2TACR3 | |
| SCHEMBL10279754 | 0.72 | AKT1 (0.49) | AKT1AKT2TACR3 | |
| SCHEMBL15116250 | 0.72 | AKT1 (0.48) | AKT1AKT2TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593458-A1 | BICYCLIC PYRIMIDINES | Bayer Intellectual Property GmbH (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007416-A1 | BICYCLIC PYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-19 | — | — | WO | disclosed |