Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 1.00 |
| ▸ | PDE5A | O76074 | 1/20 | 0.84 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.84 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.84 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.84 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362623 | 0.93 | PDE10A (0.94) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362490 | 0.91 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363821 | 0.90 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363261 | 0.89 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363986 | 0.88 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362144 | 0.87 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363435 | 0.87 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL361706 | 0.85 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362581 | 0.84 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL368463 | 0.83 | PDE10A (0.78) | PDE10APDE5APDE1BPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |