Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 1.00 |
| ▸ | APP | P05067 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.80 |
| ▸ | CTSD | P07339 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360957 | 1.00 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL362434 | 0.91 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL362828 | 0.91 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL15345214 | 0.89 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL10469283 | 0.89 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL360548 | 0.88 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL29430233 | 0.88 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL14325981 | 0.88 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL361158 | 0.87 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 | |
| SCHEMBL361406 | 0.87 | BACE1 (1.00) | BACE1BACE2APPCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140088084-A1 | OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | HOLZER PHILIPP (CH) | 2014-03-27 | — | — | US | disclosed |
| WO-2011009943-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088084-A1 | OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | OTC, GRIK5, GRIN2C | BACE1 69/4885BACE2 161/4885APP 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.