Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627056 | 0.84 | KCNA5 (0.48) | TACR1KCNA5KCNH2DPP4KDM4E | |
| SCHEMBL3622912 | 0.82 | KCNA5 (0.45) | TACR1KCNA5KCNH2DPP4KDM4E | |
| SCHEMBL3626880 | 0.81 | KCNA5 (0.39) | TACR1KCNA5KCNH2PGRNR1H3 | |
| SCHEMBL3627068 | 0.81 | KCNA5 (0.54) | KCNA5KCNH2PGRKDM4EGLA | |
| SCHEMBL1381734 | 0.81 | KCNA5 (0.68) | KCNA5KCNH2PGRKDM4EALDH1A1 | |
| SCHEMBL3621940 | 0.81 | DPP4 (0.62) | TACR1KCNA5KCNH2DPP4KDM4E | |
| SCHEMBL3624343 | 0.81 | KCNA5 (0.44) | KCNA5KCNH2DPP4KDM4EALDH1A1 | |
| SCHEMBL3627274 | 0.81 | DPP4 (0.47) | KCNA5KCNH2DPP4KDM4EALDH1A1 | |
| SCHEMBL3621922 | 0.79 | KCNA5 (0.45) | TACR1KCNA5KCNH2PGRDPP4 | |
| SCHEMBL3616349 | 0.79 | KCNA5 (0.64) | KCNA5KCNH2DPP4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | claimed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNQ5 | TACR1 2086/4885KCNA5 14/4885KCNH2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.