Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.79 |
| ▸ | PDE5A | O76074 | 1/20 | 0.79 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.79 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.79 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.79 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359719 | 0.89 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362764 | 0.88 | PDE10A (0.79) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362917 | 0.82 | PDE10A (0.79) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363959 | 0.78 | PDE10A (0.79) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL361777 | 0.75 | PDE10A (0.68) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL363960 | 0.71 | PDE10A (0.67) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362925 | 0.67 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL362724 | 0.67 | PDE10A (0.59) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL20457000 | 0.66 | PDE10A (0.71) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL361700 | 0.65 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |