Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368974 | 0.74 | GPBAR1 (0.70) | GPBAR1HTR2ACNR1SLC6A2SLC6A4 | |
| SCHEMBL368975 | 0.74 | GPBAR1 (0.70) | GPBAR1HTR2ACNR1SLC6A2SLC6A4 | |
| SCHEMBL368976 | 0.74 | GPBAR1 (0.70) | GPBAR1HTR2ACNR1SLC6A2SLC6A4 | |
| SCHEMBL1389633 | 0.73 | GPBAR1 (0.46) | GPBAR1HTR2ACNR1SLC6A2SLC6A4 | |
| SCHEMBL1389631 | 0.73 | GPBAR1 (0.46) | GPBAR1HTR2ACNR1SLC6A2SLC6A4 | |
| SCHEMBL365184 | 0.73 | GPBAR1 (0.46) | GPBAR1HTR2ACNR1SLC6A2SLC6A4 | |
| SCHEMBL10240912 | 0.73 | GPBAR1 (0.49) | GPBAR1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL364472 | 0.73 | GPBAR1 (0.49) | GPBAR1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1389558 | 0.73 | GPBAR1 (0.49) | GPBAR1HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL369817 | 0.72 | EPHX2 (0.52) | GPBAR1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |