Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 13/20 | 0.55 |
| ▸ | PPARA | Q07869 | 9/20 | 0.55 |
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2107711 | 0.85 | PPARD (0.61) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL2108828 | 0.76 | PPARD (0.58) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL2108166 | 0.74 | PPARD (0.71) | PPARDPPARAPPARGFFAR1CHRM5 | |
| SCHEMBL2107504 | 0.72 | PPARD (0.70) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL2108352 | 0.71 | ALDH2 (0.48) | PPARDPPARA | |
| SCHEMBL2109131 | 0.70 | PPARD (0.67) | PPARDPPARAPPARGFFAR1CHRM5 | |
| SCHEMBL3663717 | 0.70 | ALDH2 (0.46) | PPARDPPARAPPARG | |
| SCHEMBL2108663 | 0.70 | PPARD (0.64) | PPARDPPARAPPARGFFAR1CHRM5 | |
| SCHEMBL6238582 | 0.69 | FFAR1 (0.76) | PPARDPPARAPPARGFFAR1CHRM5 | |
| SCHEMBL5017180 | 0.69 | PPARD (0.60) | PPARDPPARAPPARGFFAR1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254878-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | Gilead Palo Alto, Inc. (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009094028-A1 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | CV THERAPEUTICS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |
| EP-2046769-A2 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | CV THERAPEUTICS, INC. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008014497-A2 | ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION | CV THERAPEUTICS, INC. (US) | 2008-01-31 | — | — | WO | disclosed |