Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 12/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617770 | 0.86 | NR1H3 (0.53) | NR1H3RORCNR1H2NR1I2 | |
| SCHEMBL3623891 | 0.84 | NR1H3 (0.52) | NR1H3RORCNR1H2NR1I2NOTUM | |
| SCHEMBL3627751 | 0.83 | NR1H3 (0.55) | NR1H3RORCNR1I2 | |
| SCHEMBL11605696 | 0.83 | NR1H3 (0.54) | NR1H3ALDH1A1RORCNR1H2NR1I2 | |
| SCHEMBL11607914 | 0.82 | NOTUM (0.64) | NR1H3ALDH1A1RORCNR1H2NR1I2 | |
| SCHEMBL11479804 | 0.81 | NR1H3 (0.52) | NR1H3RORCNR1H2NR1I2NOTUM | |
| SCHEMBL3627747 | 0.80 | NR1H3 (0.58) | NR1H3ALDH1A1RORCNR1H2 | |
| SCHEMBL11610638 | 0.79 | NR1H3 (0.54) | NR1H3ALDH1A1RORCNR1H2NR1I2 | |
| SCHEMBL11468470 | 0.78 | NR1H3 (0.49) | NR1H3ALDH1A1RORCNR1H2NR1I2 | |
| SCHEMBL11472558 | 0.78 | NR1H3 (0.51) | NR1H3ALDH1A1RORCNR1H2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741317-B2 | LXR modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-22 | — | — | US | disclosed |
| US-20070093470-A1 | LXR modulators | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093470-A1 | LXR modulators | NR1H2, NR1H3, RXRB | NR1H3 2/4885ALDH1A1 2274/4885RORC 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.