Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.67 |
| ▸ | DPP4 | P27487 | 3/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639832 | 0.90 | KCNA5 (0.68) | KCNA5KCNH2DPP4MAPK8ALDH1A1 | |
| SCHEMBL13283560 | 0.90 | KCNA5 (0.59) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL3122092 | 0.89 | KCNA5 (0.75) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL3627103 | 0.89 | KCNA5 (0.58) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL3625509 | 0.88 | KCNA5 (0.57) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL3625029 | 0.86 | KCNA5 (0.51) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL3620771 | 0.86 | KCNA5 (0.52) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL13256468 | 0.85 | KCNA5 (0.70) | KCNA5KCNH2DPP4MAPK8 | |
| SCHEMBL13379985 | 0.84 | KDM4E (0.53) | KCNA5KCNH2DPP4KDM4EALDH1A1 | |
| SCHEMBL3618662 | 0.84 | KCNA5 (0.68) | KCNA5KCNH2DPP4MAPK8L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | claimed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | claimed |
| US-7763614-B2 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| EP-1667981-A4 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-08 | — | — | US | disclosed |
| EP-1667981-A1 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030729-A1 | ISOQUINOLINE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054892-A1 | Isoquinoline potassium channel inhibitors | KCNQ1, KCNQ2, KCNQ5 | KCNA5 14/4885KCNH2 5/4885DPP4 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.