⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032219 | 0.76 | — | — | |
| SCHEMBL3601925 | 0.67 | — | — | |
| SCHEMBL9830453 | 0.64 | — | — | |
| SCHEMBL3751940 | 0.62 | — | — | |
| SCHEMBL18872026 | 0.62 | — | — | |
| SCHEMBL1679515 | 0.62 | — | — | |
| SCHEMBL19202494 | 0.62 | — | — | |
| SCHEMBL8266084 | 0.62 | — | — | |
| SCHEMBL13674570 | 0.62 | — | — | |
| SCHEMBL7265383 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035419-B1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER IP GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| US-8399471-B2 | Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-19 | — | — | US | disclosed |
| US-20100035902-A1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2010-02-11 | — | — | US | disclosed |
| EP-2035419-A1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | Bayer HealthCare AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| CN-101304970-A | Amorphous form of 1, 2-dihydropyridine compound | EISAI R&D MAN CO LTD (JP) | 2008-11-12 | — | — | CN | disclosed |
| WO-2007140894-A1 | 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2007-12-13 | — | — | WO | disclosed |
| US-6066737-A | Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine | CHIROTECH TECHNOLOGY, LTD. (GB) | 2000-05-23 | — | — | US | disclosed |
| EP-0874820-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ENRICHED 4-ARYL-3-HYDROMETHYL SUBSTITUTED PIPERIDINES TO BE USED AS INTERMEDIATES IN THE SYNTHESIS OF PAROXETINE | Chirotech Technology Limited (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024323-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ENRICHED 4-ARYL-3-HYDROMETHYL SUBSTITUTED PIPERIDINES TO BE USED AS INTERMEDIATES IN THE SYNTHESIS OF PAROXETINE | CHIROTECH TECHNOLOGY (GB) | 1997-07-10 | — | — | WO | disclosed |