Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16845137 | 0.91 | HPGD (0.50) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL310354 | 0.91 | HPGD (0.51) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL24183616 | 0.89 | HPGD (0.51) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL24267253 | 0.86 | HPGD (0.53) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL15017274 | 0.85 | HPGD (0.49) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL15017470 | 0.85 | HPGD (0.49) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL8276848 | 0.84 | RECQL (0.54) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL8056889 | 0.84 | RECQL (0.54) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL264879 | 0.84 | RECQL (0.54) | RECQLHPGDUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL117231 | 0.84 | HPGD (0.48) | RECQLHPGDUSP2SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142537-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008115973-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-25 | — | — | WO | disclosed |