SCHEMBL3625819

SCHEMBL3625819

F[CH]COc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 3/20 0.54
KCNA3 P22001 1/20 0.50
MAOB P27338 3/20 0.47
AOC2 O75106 2/20 0.47
MAOA P21397 2/20 0.47
DAO P14920 1/20 0.47
TAAR1 Q96RJ0 1/20 0.44
ALDH1A1 P00352 1/20 0.44
RECQL P46063 1/20 0.44
ALOX15 P16050 1/20 0.43
LTA4H P09960 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10477050 0.81 AOC3 (0.61) AOC3KCNA3MAOBAOC2MAOA
SCHEMBL10477051 0.81 AOC3 (0.61) AOC3KCNA3MAOBAOC2MAOA
SCHEMBL419306 0.79 AOC3 (0.78) AOC3KCNA3TAAR1ALDH1A1RECQL
SCHEMBL1445312 0.79 AOC3 (0.58) AOC3KCNA3TAAR1ALDH1A1RECQL
SCHEMBL419305 0.79 AOC3 (0.78) AOC3KCNA3TAAR1ALDH1A1RECQL
SCHEMBL9486588 0.76 KCNA3 (0.65) KCNA3TAAR1ALDH1A1RECQLLTA4H
SCHEMBL9486653 0.76 KCNA3 (0.58) KCNA3MAOBAOC2MAOADAO
SCHEMBL5709101 0.75 AOC3 (0.54) AOC3KCNA3TAAR1ALDH1A1RECQL
SCHEMBL8526568 0.75 AOC3 (0.54) AOC3KCNA3TAAR1ALDH1A1RECQL
SCHEMBL4154296 0.75 AOC3 (0.54) AOC3KCNA3TAAR1ALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105037208-A N-(1-methyl-2-substituted methyl) valine amide carbamate derivative and application UNIV NANKAI 2015-11-11 CN claimed
CN-104016886-A N-1,2-disubstituted ethyl valinamide carbamate derivative and application thereof UNIV NANKAI 2014-09-03 CN claimed
WO-2016160938-A1 N-(1,3-THIAZOL-2-YL)PYRIMIDINE-5-CARBOXAMIDES AS TRPV3 MODULATORS ABBVIE INC. (US) 2016-10-06 WO disclosed
CN-105037208-A N-(1-methyl-2-substituted methyl) valine amide carbamate derivative and application UNIV NANKAI 2015-11-11 CN disclosed
CN-104016886-A N-1,2-disubstituted ethyl valinamide carbamate derivative and application thereof UNIV NANKAI 2014-09-03 CN disclosed
EP-2178373-A1 HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS Icagen, Inc. (US) 2010-04-28 EP disclosed
WO-2009026254-A1 HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS ICAGEN, INC. (US) 2009-02-26 WO disclosed
US-5192767-A Nonphytotoxic BASF AKTIENGESELLSCHAFT (DE) 1993-03-09 US disclosed
EP-0311907-A2 3-Substituted pyridines and fungicides containing them BASF Aktiengesellschaft (DE) 1989-04-19 EP disclosed