Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626429 | 0.86 | LDLR (0.45) | LDLRHDAC11HPGDSMN1; SMN2NPC1 | |
| SCHEMBL1923364 | 0.85 | LDLR (0.44) | LDLRHDAC11HPGDSMN1; SMN2NPC1 | |
| SCHEMBL304418 | 0.83 | LDLR (0.41) | LDLRHDAC11HPGDSMN1; SMN2NPC1 | |
| SCHEMBL2031910 | 0.82 | LDLR (0.42) | LDLRHDAC11HPGDSMN1; SMN2NPC1 | |
| SCHEMBL303820 | 0.81 | LDLR (0.43) | LDLRHDAC11HPGDSMN1; SMN2NPC1 | |
| SCHEMBL304307 | 0.80 | LDLR (0.46) | LDLRHDAC11SMN1; SMN2KDRTP53 | |
| SCHEMBL3658672 | 0.77 | MAPT (0.36) | TP53MAPTLMNAGAA | |
| SCHEMBL303622 | 0.75 | PTGDR2 (0.41) | LDLRHPGDSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL27935545 | 0.75 | LDLR (0.36) | LDLRHDAC11HPGDALDH1A1NPSR1 | |
| SCHEMBL302156 | 0.75 | LDLR (0.41) | LDLRHPGDSMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | claimed |