Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.40 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627330 | 0.92 | GUCY1B2 (0.40) | S1PR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3626338 | 0.92 | S1PR1 (0.45) | S1PR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3628358 | 0.90 | GUCY1B2 (0.41) | S1PR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3625821 | 0.88 | GUCY1B2 (0.42) | S1PR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3624462 | 0.86 | EPHX2 (0.40) | S1PR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3627404 | 0.82 | GUCY1B2 (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1HPGD | |
| SCHEMBL3628719 | 0.81 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1NEK2 | |
| SCHEMBL3998841 | 0.81 | S1PR1 (0.48) | S1PR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3624888 | 0.81 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1HPGD | |
| SCHEMBL3629056 | 0.80 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |