Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13287434 | 1.00 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2851801 | 1.00 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2851945 | 0.94 | MAPK14 (0.70) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2851949 | 0.94 | MAPK14 (0.70) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL13287648 | 0.94 | MAPK14 (0.70) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2853787 | 0.91 | MAPK14 (0.69) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL13287495 | 0.91 | MAPK14 (0.69) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2853790 | 0.91 | MAPK14 (0.69) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2846973 | 0.88 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL2846978 | 0.88 | MAPK14 (0.65) | MAPK14MAPK11ROCK2MAPK12STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166857-A1 | KINASE INHIBITOR COMPOUNDS | Xcovery, INC. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008153942-A1 | KINASE INHIBITOR COMPOUNDS | XCOVERY, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008153942-A1 | KINASE INHIBITOR COMPOUNDS | XCOVERY, INC. (US) | 2008-12-18 | — | — | WO | disclosed |