SCHEMBL3629454

SCHEMBL3629454

COc1ncc(Cl)nc1NS(=O)(=O)c1ccc(F)c(F)c1F.COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1C

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 19/20 0.68
EDNRA P25101 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1732852 0.90 CCR4 (0.63) CCR4EDNRA
SCHEMBL1732932 0.90 CCR4 (0.83) CCR4EDNRA
SCHEMBL1731472 0.81 CCR4 (1.00) CCR4EDNRA
SCHEMBL1731964 0.80 CCR4 (1.00) CCR4
SCHEMBL1731810 0.80 CCR4 (0.82) CCR4EDNRA
SCHEMBL1733142 0.78 CCR4 (1.00) CCR4EDNRA
SCHEMBL1972347 0.77 CCR4 (0.81) CCR4EDNRA
SCHEMBL1733179 0.76 CCR4 (0.68) CCR4EDNRA
SCHEMBL1731980 0.76 CCR4 (0.72) CCR4
SCHEMBL1732589 0.75 CCR4 (0.83) CCR4EDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7662825-B2 2,3-Dichloro-N-(3-methoxy-5-methyl-2-pyrazinyl)-benzenesulphonamide; inflammatory diseases, such as asthma ASTRAZENECA AB (SE) 2010-02-16 US claimed