Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 6/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627871 | 0.91 | PDE4B (0.47) | SSTR5PDE4BJAK1 | |
| SCHEMBL3628823 | 0.89 | SSTR5 (0.38) | SSTR5HRH1HTR2BALDH1A1KDM4E | |
| SCHEMBL3632894 | 0.89 | KDM4E (0.38) | SSTR5CCR5HRH1HTR2BALDH1A1 | |
| SCHEMBL3628821 | 0.88 | SSTR5 (0.45) | SSTR5CCR5HRH1ALDH1A1KDM4E | |
| SCHEMBL3633056 | 0.87 | SSTR5 (0.36) | SSTR5CCR5HRH1HTR2BALDH1A1 | |
| SCHEMBL3632221 | 0.87 | SSTR5 (0.46) | SSTR5HRH1HTR2BALDH1A1KDM4E | |
| SCHEMBL3630409 | 0.85 | SSTR5 (0.37) | SSTR5JAK2JAK1 | |
| SCHEMBL3632031 | 0.85 | SSTR5 (0.43) | SSTR5HRH1HTR2BKMT2AJAK2 | |
| SCHEMBL3631979 | 0.81 | SSTR5 (0.46) | SSTR5PDE4BKDM4EKMT2ANPSR1 | |
| SCHEMBL3630712 | 0.81 | SSTR5 (0.53) | SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-A1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008122510-A1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-16 | — | — | WO | claimed |