Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 15/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510327 | 0.94 | NR1H2 (0.61) | NR1H2NR1H3RXRA | |
| SCHEMBL3507631 | 0.87 | ESR1 (0.42) | NR1H2PTGS2 | |
| SCHEMBL3511764 | 0.86 | NR1H2 (0.62) | NR1H2NR1H3 | |
| SCHEMBL3509019 | 0.83 | NR1H2 (0.60) | NR1H2NR1H3RXRA | |
| SCHEMBL3505942 | 0.82 | NR1H2 (0.64) | NR1H2NR1H3RXRA | |
| SCHEMBL3509369 | 0.81 | NR1H2 (0.58) | NR1H2NR1H3RXRA | |
| SCHEMBL3507737 | 0.80 | NR1H2 (0.64) | NR1H2NR1H3RXRA | |
| SCHEMBL3507401 | 0.80 | NR1H2 (0.61) | NR1H2NR1H3RXRA | |
| SCHEMBL3505275 | 0.78 | NR1H2 (0.55) | NR1H2NR1H3RXRA | |
| SCHEMBL3507120 | 0.78 | NR1H2 (0.62) | NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142517-A2 | QUINAZOLINE COMPOUNDS | Wyeth (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2009020683-A2 | QUINAZOLINE COMPOUNDS | WYETH (US) | 2009-02-12 | — | — | WO | disclosed |