Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 3/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363170 | 1.00 | BACE1 (0.39) | BACE1APPCTSDBACE2IDO1 | |
| SCHEMBL360846 | 0.86 | BACE1 (0.36) | BACE1APPCTSD | |
| SCHEMBL360847 | 0.86 | BACE1 (0.36) | BACE1APPCTSD | |
| SCHEMBL12273081 | 0.81 | BACE1 (0.39) | BACE1APPCTSDBACE2 | |
| SCHEMBL362319 | 0.81 | BACE1 (0.39) | BACE1APPCTSDBACE2 | |
| SCHEMBL360988 | 0.78 | BACE1 (0.37) | BACE1APPCTSDBACE2 | |
| SCHEMBL362625 | 0.78 | BACE1 (0.37) | BACE1APPCTSDBACE2 | |
| SCHEMBL1173442 | 0.67 | BACE1 (0.39) | BACE1APPCTSDBACE2 | |
| SCHEMBL1173165 | 0.67 | BACE1 (0.39) | BACE1APPCTSDBACE2 | |
| SCHEMBL1173162 | 0.67 | BACE1 (0.39) | BACE1APPCTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483255-A1 | OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2012-08-08 | — | — | EP | disclosed |
| WO-2012006953-A1 | OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2012-01-19 | — | — | WO | disclosed |