Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363843 | 0.88 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL370867 | 0.87 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL357693 | 0.86 | PIK3CD (0.74) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL357012 | 0.85 | PIK3CD (0.75) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL358381 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL16564494 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL358615 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL359553 | 0.85 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL357822 | 0.85 | PIK3CD (0.71) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL357668 | 0.84 | PIK3CD (0.88) | PIK3CDPIK3CBPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593455-A1 | PURINE COMPOUNDS SELECTIVE FOR I3 P110 DELTA, AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007493-A1 | PURINE COMPOUNDS SELECTIVE FOR ΡI3Κ P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |