Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.45 |
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | CTSD | P07339 | 4/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27774263 | 0.83 | BACE1 (0.47) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL27740597 | 0.83 | BACE1 (0.47) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL27774265 | 0.82 | BACE1 (0.62) | BACE1RENCTSDBACE2 | |
| SCHEMBL27774262 | 0.82 | BACE1 (0.52) | BACE1RENCTSDBACE2 | |
| SCHEMBL3632416 | 0.81 | BACE1 (0.45) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL27719408 | 0.80 | BACE1 (0.52) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL21993239 | 0.79 | BACE1 (0.57) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL3630350 | 0.78 | BACE1 (0.51) | BACE1RENCTSDBACE2 | |
| SCHEMBL2793362 | 0.77 | BACE1 (0.76) | BACE1RENCTSDBACE2CYP3A4 | |
| SCHEMBL2797586 | 0.76 | BACE1 (0.66) | BACE1RENCTSDBACE2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144884-A2 | AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | Wyeth a Corporation of the State of Delaware (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008118379-A2 | AMINO-5-[4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF β-SECRETASE | WYETH (US) | 2008-10-02 | — | — | WO | disclosed |