Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.69 |
| ▸ | FYN | P06241 | 12/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | FUBP1 | Q96AE4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13595838 | 0.84 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL3512829 | 0.82 | FYN (0.73) | PIK3CAFYNATR | |
| SCHEMBL4054058 | 0.82 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL3514490 | 0.82 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL3513764 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL3514614 | 0.81 | FYN (0.64) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL3512458 | 0.80 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL4054806 | 0.80 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL4054197 | 0.80 | FYN (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGFYN | |
| SCHEMBL4054305 | 0.79 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155753-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | Novartis Ag (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008138834-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | claimed |