Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977562 | 0.85 | POLB (0.97) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL23089669 | 0.85 | POLB (0.90) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL14134639 | 0.84 | POLB (1.00) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL29279181 | 0.83 | POLB (0.74) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL3203109 | 0.81 | POLB (0.72) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL30693019 | 0.81 | POLB (0.72) | POLBALDH1A1CYP2D6LMNAGAA | |
| SCHEMBL3149654 | 0.81 | POLB (0.72) | POLBALDH1A1CYP2D6LMNAGAA | |
| SCHEMBL2980751 | 0.80 | POLB (0.70) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL12751726 | 0.79 | POLB (0.68) | POLBALDH1A1CYP2D6L3MBTL1LMNA | |
| SCHEMBL24058319 | 0.79 | POLB (0.68) | POLBALDH1A1CYP2D6LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162455-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | Glaxo Group Limited (GB) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008145688-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |