Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 9/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.67 |
| ▸ | MTOR | P42345 | 5/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.63 |
| ▸ | PRKDC | P78527 | 1/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3085931 | 0.88 | PIK3CG (0.68) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3094883 | 0.88 | PIK3CG (0.85) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3632905 | 0.87 | PIK3CG (0.49) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3084297 | 0.84 | PIK3CA (0.70) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3082086 | 0.83 | PIK3CD (0.71) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3072056 | 0.83 | PIK3CD (0.68) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3091501 | 0.82 | PIK3CG (0.68) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3092697 | 0.81 | PIK3CA (0.70) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3091645 | 0.81 | PIK3CD (0.84) | PIK3CBPIK3CGMTORPIK3CAPIK3CD | |
| SCHEMBL3092416 | 0.81 | PIK3CA (0.64) | PIK3CBPIK3CGMTORPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |