Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | NPY1R | P25929 | 1/20 | 0.65 |
| ▸ | NPY2R | P49146 | 1/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3641483 | 0.90 | MAPT (0.62) | MAPTTP53ABCB1MEN1KMT2A | |
| SCHEMBL3641993 | 0.89 | ABCB1 (0.68) | MAPTABCB1MEN1KMT2AKCNH2 | |
| SCHEMBL3637761 | 0.88 | MAPT (0.60) | MAPTABCB1MEN1KMT2AMAPK1 | |
| SCHEMBL8609331 | 0.86 | MAPT (0.66) | MAPTTP53HTTABCB1MEN1 | |
| SCHEMBL2017556 | 0.85 | KCNH2 (0.81) | MAPTHTTABCB1MEN1KMT2A | |
| SCHEMBL2017559 | 0.85 | KCNH2 (0.81) | MAPTHTTABCB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11095607 | 0.81 | MEN1 (0.53) | MAPTTP53HTTNPY1RNPY2R | |
| SCHEMBL28632862 | 0.80 | MAPK1 (0.91) | MAPTTP53MEN1KMT2AMAPK1 | |
| SCHEMBL11826883 | 0.80 | MAPT (0.80) | MAPTTP53HTTNPY1RNPY2R | |
| SCHEMBL2021188 | 0.79 | KCNH2 (0.81) | MAPTHTTABCB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | Emory University (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |