Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | RORA | P35398 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | RORB | Q92753 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340084 | 0.89 | GPBAR1 (0.35) | GPBAR1RORARORCRORB | |
| SCHEMBL3338302 | 0.89 | CHRM4 (0.36) | GPBAR1CHRM4RORARORCRORB | |
| SCHEMBL31683687 | 0.89 | CHRM4 (0.36) | GPBAR1CHRM4RORARORCRORB | |
| SCHEMBL30509048 | 0.82 | GPBAR1 (0.39) | GPBAR1RORARORCRORB | |
| SCHEMBL3338812 | 0.81 | GPBAR1 (0.40) | GPBAR1RORARORCRORB | |
| SCHEMBL30993924 | 0.81 | GPBAR1 (0.40) | GPBAR1RORARORCRORB | |
| SCHEMBL23811152 | 0.81 | CHRM4 (0.38) | GPBAR1CHRM4RORARORCRORB | |
| SCHEMBL4753004 | 0.80 | CHRM4 (0.35) | GPBAR1CHRM4RORCPOLB | |
| SCHEMBL30509090 | 0.79 | GPBAR1 (0.41) | GPBAR1RORARORCRORB | |
| SCHEMBL23800928 | 0.79 | GPBAR1 (0.41) | GPBAR1RORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155194-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008124610-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |