Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 11/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5064647 | 0.86 | KDR (0.48) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL5064666 | 0.85 | KDR (0.52) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL5067416 | 0.85 | KDR (0.51) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL5064651 | 0.84 | KDR (0.51) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL3665903 | 0.83 | KDR (0.48) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL3666008 | 0.83 | KDR (0.48) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL5064068 | 0.83 | KDR (0.48) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL5067452 | 0.80 | KDR (0.51) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL3798475 | 0.80 | KDR (0.46) | KDRFGFR1BRAFMAPK14TNNI3K | |
| SCHEMBL3666384 | 0.79 | KDR (0.47) | KDRFGFR1BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146718-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008131253-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |