Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630393 | 1.00 | GAA (0.85) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL3600256 | 0.97 | GAA (0.81) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL9987759 | 0.97 | GAA (0.81) | GAAALDH1A1KMT2AMEN1HTT | |
| Hydrochloric Acid SCHEMBL27685977 | 0.95 | GAA (0.77) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL15283000 | 0.94 | GAA (0.95) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL11142722 | 0.88 | — | — | |
| SCHEMBL13902800 | 0.82 | GAA (0.79) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL28551255 | 0.80 | GAA (0.63) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL8978099 | 0.79 | GAA (0.70) | GAAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL1377365 | 0.79 | GAA (0.62) | GAAALDH1A1KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155687-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141976-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |