Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 15/20 | 0.69 |
| ▸ | CDC7 | O00311 | 3/20 | 0.60 |
| ▸ | CDK9 | P50750 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | GRK5 | P34947 | 1/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.60 |
| ▸ | CDK8 | P49336 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | CDK7 | P50613 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1603214 | 0.83 | PDPK1 (0.66) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1603905 | 0.83 | PDPK1 (0.80) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1604071 | 0.82 | PDPK1 (0.78) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1603523 | 0.82 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1604009 | 0.81 | PDPK1 (0.77) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1604217 | 0.81 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1603808 | 0.80 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1604041 | 0.79 | PDPK1 (1.00) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1603855 | 0.79 | PDPK1 (0.81) | PDPK1CDC7CDK9CDK5DYRK1A | |
| SCHEMBL1603564 | 0.79 | PDPK1 (0.77) | PDPK1CDC7CDK9CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155745-A1 | 6-(PYRROLOPYRIDINYL)-PYRIMIDINE-2-YL-AMINE DERIVATIVES | Merck Patent GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008155000-A1 | 6-(PYRROLOPYRIDINYL)-PYRIMIDINE-2-YL-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-12-24 | — | — | WO | disclosed |